Doctor Jolene faces one of her most serious cases yet; Martika's autoimmune disease has turned a simple infection into a life-threatening emergency. Time is of the essence for Doctor Javed as he treats his first traumatic sports injury. Doctor Laura has recently stepped up to the role of junior registrar. She’s now expected to make many clinical decisions on her own. But one of her cases has no simple answers.

Doctor Caitriona is put under pressure inserting a cannula into an elderly patient in desperate need of intravenous medication to save her life. On his first day in Children’s ED, Doctor Javed is way out of his comfort zone, reassuring an 11-year-old with a phobia of needles. While Doctor Eoin must act fast to insert a breathing tube into a drug overdose patient, at risk of choking on his own vomit.

In his most urgent trauma case yet, Doctor Conor must treat a 17-year-old airlifted to hospital with suspected spinal injuries, following a quad bike accident. Irish doctor Jolene is confronted with a patient having an adverse reaction to a jellyfish sting – something she’s never seen before. And a camping trip gone wrong leaves Doctor Natalie treating an 18-year-old with a disturbing injury to his leg.

Doctor Eoin is searching for answers and stronger painkillers when a 57-year-old woman presents to ED with excruciating chest pain. Doctor Natalie is concerned her 76-year-old patient, brought in by ambulance, is suffering from a life-threatening blood clot. And Doctor Javed must work with his senior to remove a steel splinter embedded in his patient’s eye.

After 10 intense weeks, the Junior Doctors have come to the end of their rotation in the Emergency Department - but there's no let up yet. Dr Jolene treats a patient whose excitable dog took her for a walk.