In the series opener, Brian and Mark meet icon, Sir Tom Jones. In conversation and song, they reminisce on their earliest musical influences and Sir Tom shares captivating stories from his career, including his friendship with Elvis Presley.

Brian and Mark visit Mark's own British Grove recording studio to meet UK singer-songwriter and fellow Geordie, Sam Fender. Sam tells the story of his musical journey so far, discusses the influence Brian and Mark have had on him and shows them how to play Seventeen Going Under.

Brian and Mark hook up with 80s icon Cyndi Lauper at New York's legendary recording studio, The Power Station. Cyndi discusses her tumultuous career in the music industry and brings her dulcimer along to teach Brian and Mark a special arrangement of her classic hit, True Colours.

In Miami, Brian and Mark meet disco legend Nile Rodgers and explore his impressive musical career, from Studio 54 to David Bowie and Daft Punk. Nile and Mark jam together on an exclusive 'Johnny Cash version' of Chic's disco classic, Good Times.

Brian and Mark travel to California to visit Carlos Santana, who recounts his incredible journey in music, from early days, through his Woodstock performance and resurgence in the late 90s. Together, they jam an amazing version of Black Magic Woman and Carlos plays some of his biggest hits.

Brian and Mark head to Music City - Nashville - and meet up with Mark's long-time friend and sometime collaborator, Emmylou Harris. Emmylou shares her career highlights and discusses her relationship with legendary country rock pioneer Gram Parsons. They're also joined for an exclusive jam session with country music superstar guitarist, Vince Gill.