Britain is in the grip of a deadly flu virus, which is now spreading throughout the world. When people start dying in their millions, a handful of survivors are left struggling to stay alive as society crumbles around them. Abby Grant is a housewife and mother who begins the desperate search for her son. On her journey she meets a variety of people whom fate has spared. The new world could be a dangerous place, and their only hope is to stick together.

Abby and her new friends discover that supplies won't be shared equally in the new world. A gang of armed thugs have laid claim to all the shops in the area leaving them short of food and water. Greg receives an attractive offer which could give him a comfortable life, but taking it would mean turning his back on the others.

Abby stumbles across a community that could hold the key to everyone's future. The last surviving member of the government, Samantha Willis, has set up a community that still boasts light, hot water, food, and power. Abby and Samantha hit it off immediately, but Abby's illusions are shattered when she sees the lengths Samantha will go to in order to maintain control of her fledgling community. Meanwhile, Greg and Tom are out searching for supplies when they encounter a family who have successfully sheltered from the virus. When the daughter of the family reaches out to Tom and Greg, they are faced with a terrible dilemma, as any contact with them could kill the family.

Abby learns of a group of young boys living at a nearby mansion called Waterhouse. She leaves her new friends in order to find her son, Peter. When she arrives at Waterhouse she walks into the middle of a land dispute between an ex-army officer and an aggressive group of teenage boys. She must try and broker a truce in order to discover if Peter is at the house. Tom, Sarah, Al and Najid are drawn to the comfort and security that Samantha's community provides. Things quickly go wrong for Al as he is ejected from the community. Tom sees the chance to prove himself to Samantha, but will his criminal past catch up with him? Greg and Anya have an encounter with some unwelcome visitors that provides a vivid reminder of how vulnerable they are without the group.

When visionary spiritual leader John turns up mysteriously at the survivors' door with his ragged group of passionate disciples, some in the house are suspicious of his motives, in the penultimate episode of Adrian Hodges' post-apocalyptic drama series. Charming and eloquent, John is a preacher with a unique perspective on the new world, but the family's opinion of him is split. Is he as innocent as he seems, or does he have more sinister motives? A woman in John's group is pregnant, and Abby allows her to stay until the baby is born. Anya fears that she will be forced to reveal that she is a doctor if there are any problems with the birth. Worse than that, she picks up on some unusual remarks by John which make her concerned for the group's safety.

In the final episode of the series Abby and her friends find themselves on the run from Samantha, who has formed a dangerous alliance that threatens everyone's freedom. Meanwhile, Sarah is confronted by a face from the past, which leads her to betray her new friends. When Naj goes missing, the family face the danger of the city in order to find him. Naj is befriended by a feral boy named Darren. Darren lives with the sinister Craig and June, who look after a group of children who forage amidst the ruins of the city in return for the shelter and protection. With his adopted family searching for him in the deserted city, time is rapidly running out, and Dexter is only a step behind them all...

Greg has been wounded by a gunshot, Anya, Al and Tom frantically search a nearby hospital to find vital medical supplies. With the building on fire, it suddenly collapses, leaving Anya and All trapped. Whilst Greg is now perilously close to death. Abby still remains kidnapped at the Lab as the Scientists seek to find a vaccine using her immune system.

The family, scavenging for survival in the city, discover that other people have been abducted in the same way as Abby. Tom, Al, Anya and Sarah set off in pursuit of a pharmaceutical company with offices in the city, while Greg and Naj are confronted by a group from which Tom has stolen supplies. At the lab, Whittaker re-infects Abby with the virus.

A passing trader betrays the family's new location to Samantha, who arranges to have Tom captured and tried for the murder of a member of her community.

Tom and Greg are enslaved alongside dozens of others in Mr Smithson's coal mine. Elsewhere, the Family are desperately tracking Billy, their only lead, across the country. At a roadside motel Billy stops to meet his girlfriend Sally and when the Family confront him, Billy claims ignorance and exits. Meanwhile in the mine, Greg formulates an escape plan, convincing Smithson that he's a geologist and has discovered a gas leak. However the Family are converging on Smithson's as well with their own rescue plans, leading to a dangerous game of cat and mouse...

Reunited and on the road, the Family travel south on the look out for a new home. They encounter a small but thriving community of survivors and decide to take up their offer of hospitality. While Al and Sarah enjoy their new romance, Tom simmers as Anya makes friends with Judy, the community's leader. Greg and Abby return to Greg's house one last time where Greg spots the mysterious postcard, leading him to an abandoned airfield and an encounter with the disturbed Mr. Stevens. Meanwhile, Sarah discovers an elderly couple dying from a new, mutant strain of the virus.

The post-apocalyptic drama reaches its thrilling conclusion as the fates of the Family, the Lab and the rest of the world come crashing together in a deadly showdown.