Dr. Robert Bolton had invented a gene-slamming device for peaceful uses until his colleague Dr. Luther Paradigm uses it for his evil purposes. When Dr. Bolton tries to intervene, he ends up gene-slammed into an unseen inhuman creature during the struggle and escapes. While in search of their father, John, Clint, Robert, and Coop are mutated into humanoid sharks by the evil Dr. Paradigm. While adapting to their new looks, the four brothers must avoid being seen.

The Street Sharks are on a runaway from the police along with their friends Bends and Dr. Lena. The Street Sharks must find a new place to live in and be safe from society.

Ripster, Jab, Streex, and Slammu must protect their reputations and change the way they are being viewed in Fission City. They must fight Dr. Piranoid as well as finding their father once and for all.

Jab and Streex are sent back in time in two different eras by Dr. Paradigm's time machine called the Time Slammer. Back in the present, Slammu, Ripster, and Bends have to deal with Dr. Piranoid's Seaviates who are now joined by Shrimp Louie. With the help of some Atlanteans, Jab is able to travel in time to save his brother Streex.

Dr. Paradigm creates Tentakill as part of his time-traveling plot to have Killamari go back to the medieval times and kill the Street Shark's ancestor Sir Thomas Bolton. Ripster and Big Slammu hijack Dr. Paradigm's Time Slammer to prevent Sir Thomas Bolton from being killed.

The Street Sharks are sent to a future where Dr. Piranoid controls everything. They meet up with Bends' great-great-grandson General Bendsini and join the rebel forces.

The Street Sharks go to Washington D.C. to save President David Horne from being "gene washed" by Dr. Piranoid as part of his plot to control President Horne after he had successfully gene-washed Vice-President Russell.

The Street Sharks and Bends travel to the country of Chernosium to help a child named Ilya (who had sent them a fan letter), rescue his father President Andre Knezevic, and overthrow a dictator named Ekerson Nozum.

After extracting alien DNA from a sample found on an asteroid, Dr. Piranoid tries to gene-slam the entire planet with this alien DNA mixed with manta ray DNA. The Street Sharks are sent up to space, per the president's request and help, to not only stop Dr. Piranoid's gene slamming plan, but also defeat the alien monster that was released from the sample. They end up getting help from Dr. Terrence Morton (who ends up becoming Mantaman in order to help fight the alien.)

Lena's brother Malik is among those who have been taking strength-enhancing pills. Ripster goes undercover to trace the source of the pills and discovers that a drug dealer named Jackal has been distributing the pills in order to get some recruits to help rob a bank.

The Street Sharks have suddenly become human again due to a formula made by Dr. Piranoid as part of a plot to keep the Street Sharks human permanently.

While investigating the killer whale attacks, the Street Sharks and Moby Lick trace the attacks to Malcolm Medusa III's marine animal sanctuary called Medusa Cove which is being covered up by holograms to hide the pollution and trapped whales. They discover that businessman Malcolm Medusa III and Clammando have been using holograms to keep the town from knowing what is really happening.

Mantaman returns to Earth to help the Street Sharks fight the energy-draining alien (which survived the space station's destruction in "Space Sharks") before it starts draining Earth's electricity.

A space capsule that landed on Earth 65,000,000 years ago has been unearthed by archaeologists. While Dr. Paradigm has taken interest in the space capsule, an incident involving the capsule's prisoner Bad Rap causes Mantaman to fall under his control (the alien whose DNA was used to create Mantaman was one of Bad Rap's many creations) as they plot to control the largest radio telescope in order to contact Bad Rap's fellow Raptors. Now the Street Sharks must work to free Mantaman before Bad Rap's transmission to his fellow Raptors gets through.

President Horne contacts the Street Sharks informing them that a UFO has been sighted in the Solar System. Upon investigating, the Street Sharks meet the Dino Vengers T-Bone, Stegz, Bullzeye, and Spike. The Street Sharks learn from them that they are after Bad Rap and the Raptors. The Street Sharks and the Dino Vengers join forces when the Raptors steal different weapons from different countries in order to make the other countries think they are being attacked by the other.

While fighting the Raptors, the Street Sharks and the Dino Vengers hear from President Horne that the military is testing their stealth Super Shadow chopper. As the Street Sharks and the Dino Vengers work to protect the Super Shadow from the Raptors, Dr. Paradigm takes interest in the Raptors as he leads Shrimp Louie and Tentakill into finding them where he will steal the Super Shadow for them in exchange for Velociraptor DNA. After Dr. Paradigm obtains the Super Shadow, the Raptors trick Dr. Paradigm by giving him iguana DNA. The Street Sharks and the Dino Vengers must work to reclaim the Super Shadow from the Raptors.

During winter, the Raptors make plans to warm up Earth in order to make it more hospitable for the Raptors. They do this by making Mt. Cauldron (a dormant volcano near Fission City) erupt by firing a missile into it so that the heat from it can be trapped in Earth's atmosphere. After the Street Sharks and the Dino Vengers thwart that plan, the Raptors do what they did on Calderas 3 by using their computer to activate every dormant volcanoes on Earth. Now the Street Sharks and the Dino Vengers must prevent the Raptors from activating the dormant volcanoes on Earth.

At the time when Big Slammu prepares for Fission City's comic book convention at a local convention center to meet his favorite comic book writer Jake Langstrom, Bullzeye learns about comic books and follows Big Slammu to the convention center. At the same time, the Raptors head to the Munitions and Armaments section of the Convention Center in order to steal the latest weaponry there.

When the Street Sharks and the Dino Vengers stop the Raptors from stealing a submarine, Stegz, Spike, and Bullzeye come down with a virus with the same symptoms as the virus the Dino Vengers once contracted on the planet Zirus 10. The Street Sharks and T-Bone race against time and the Raptors to the Amazon Rainforest to get to a special pharmaceutical fungus that would help cure the sick Dino Vengers before its final symptom takes its toll on them in the next 24 hours.

In order to track the Dino Vengers to their lair, the Raptors cause havoc at an amusement park and ambush the Dino Vengers where they managed to secretly place a tracking device on Stegz so that they can find the Dino Lair. When the Dino Vengers end up defeated and captured as part of Bad Rap's plot to launch them to the stars in a stolen missile, the Street Sharks must rescue the Dino Vengers before the Raptors can launch the missile they are on.

At the time when the World Leaders have come to an agreement not to use biological weapons, the Street Sharks and the Dino Vengers are enlisted to guard a top secret facility that the biological weapons are going to be safely destroyed. In order for the Raptors to prevent the biological weapons from being destroyed, Dr. Paradigm (who is now Dr. Iguanoid) puts the finishing touches on his mind-control chip which they plan to use on Bad Rap's alien creation after freeing it. This leads up to Dr. Iguanoid releasing the other alien in the facility as part of his plot to rule Earth.