Sword destroys a Horror that has been killing people, causing considerable destruction in the process. Meanwhile, Sophie consults the fortune teller "Moon Wizard" to locate her missing brother, but he turns into a Horror. She only just escapes with her life and then Sword arrives on his motorcycle and destroys it. Sword then takes her to his favorite diner and Makai headquarters for a meal. It appears that they both seek "El Dorado". He promises to protect her although he also asks her to be bait for a Horror who has been hunting red-haired women. The strategy works and Sword destroys the Horror, however again causing considerable destruction.

Following massive damage to a city bridge during Sword's battle with a Horror, Luke fires his special gun into the sky, causing it to rain and wiping the memories of everyone in the vicinity. Luke meets Sword in the diner, berating him for his irresponsible methods. Later Hardy, a former world champion runner who is now crippled in a wheelchair, allows himself to be possessed so he is able to run again. Finding Hardy gone, his girlfriend Enith asks Sword for help to find him. Meanwhile Hardy is now a Horror and has developed a hunger for human flesh. Hardy returns home and attempts to kill Enith but Sword intercepts him, however Hardy is too fast and it takes the combined efforts of Sword and Luke to destroy him. Again, Luke uses his rain-making gun to wipe the events from the memories of everyone in the vicinity including Enith who resumes her search for the missing Hardy.

Sword's old acquaintance, Makai Alchemist Gina, is in town to investigate an up and coming gangster named Damian Stewart because of his apparent access to the city’s information network. Sword is disinterested until Gina mentions Damian may have information on "El Dorado". Meanwhile Gang bosses gather to plot against Damian, but he because he already knows about the meeting, he ambushes them. Damian then takes a surviving gang boss and feeds him to his massive computer system which is possessed by a Horror. Sword agrees to cooperate with Gina to discover Damian's secret. She infiltrates one of Damian's exclusive pool parties and obtains a sample of his DNA to breach the security system, giving Sword an opportunity to investigate. Sword finds the possessed computer which tries to kill him, but he manages to destroy it instead. Although Sword spares Damian's life, the surviving gangsters take their revenge on him.

Sophie's roommate tells her that Father Ripley went missing and Sophie goes to find out more about his disappearance. He apparently lived with his sister Marie in a renovated church. At the residence she finds Marie living alone, looking frail and sickly. Suddenly Sword arrives and presents Marie with a bunch of flowers for the loss of her brother. Sophie and Marie share their stories, and become friendly, but that evening, when the talk turns to her brother Father Ripley, Marie has a flashback to when her brother treated her badly and imprisoned her in the basement. Marie suddenly changes and becomes violent and, fearing for her life, Sophie tries to escape. She finds herself locked in the basement which is filled with instruments of torture. Marie bursts into the basement and transforms into a Horror, but Sword arrives and a battle ensues. Although Sophie tries to help and is almost killed, but is saved by Sword's motorcycle. She again pleads with Sword to help her find her brother.

Sword and Sophie stop in a western town, Sun Dell Dios, while they wait for reinforcements. However the town is run by a vigilante group led by the sheriff Alfil. The townspeople try to take Sword into custody because they believe he kidnapped Sophie, while the waitress, Natalia, grabs Sophie and Alfil drives them out of town. When Natalia tries to sedate Sophie, she causes the car to crash. Back in town, Sword runs from the townspeople, unwilling to harm humans, and is eventually rescued by the arrival of Gina. Meanwhile Alfil reveals that he is a Horror and prepares to take Sophie captive, but she shoots him before he changes, and gains a reprieve until Sword arrives. While Sword fights the Horror Alfil, Bishop appears and prepares to take Sophie whom he calls princess, but again Gina comes to the rescue. Realizing the usefulness of the town has ended, Bishop reduces it to dust, however Gina had taken the precaution of placing a barrier around the townspeople so they were saved. As Sword, Gina and Sophie prepare to continue their journey, Zaruba compliments Sophie on her resourcefulness.