Actor and comedian Jim Belushi is adding another expertise to his repertoire…cannabis farmer! Jim learns the hard way that the "I'll do it myself" mentality leads to mistakes. Later, Jim discovers that his family's support for his new endeavor is waning.

Jim and Chris are on their way to Idaho for a Blues Brothers show with Dan Aykroyd, where Jim plans to ask Dan for the right to use the Blues Brothers' brand. Dan sets Jim on a "Mission from God" -- to Colombia, in pursuit of elusive cannabis strains.

After losing the seeds of two prized Colombian strains, Jim and Chris are back at square one. The cousins explore Pablo Escobar's old haunts while trying to salvage their trip. Back home, they celebrate the harvest of Jim's strains with a big party.

Jim realizes his cannabis farm needs to be re-built from the ground up. To make matters worse, Jim is terrified that Dan Aykroyd will take the Blues Brothers brand away from him.

As the farm rebuilds, Jim gets a visit from his friend Guy Fieri, and Guy tastes Jim's cannabis-infused ice cream with surprising results. Jim puts his son Jared through a torturous test to see if he's deserving of inheriting the farm.

Jim's daughter, Jami, arrives with the intention of taking over the operation of the farm, much to Jared's dismay. Jim's friends and colleagues gather to celebrate his birthday and the completion of the rebuild. - but then tragedy strikes.

A suspicious fire on the farm has Jim Belushi and his staff fearing for their safety and the future of the farm. But after being presented with exciting expansion opportunities, Jim makes a brash decision that could send the entire business up in smoke.

Going against everyone's wishes, Jim Belushi makes a major decision that creates chaos for his entire staff. Meanwhile, with Jim and Chris away on business, Larry sets his sights on taking over the farm.

Dan Aykroyd presents Jim and Chris with a hair-brained scheme that sends them deep into the woods of Big Sur, California, in search of a legendary marijuana seed. Meanwhile, Larry investigates a murder on the farm.

Chris sells Jim on buying a "turnkey facility" in Illinois, but the operation turns out to be growing bunk weed and will need a complete overhaul. Back on the farm, Larry continues his reign of terror.

Jim and Chris' trip to Mississippi, for their final leg of this part of their national expansion, comes to a halt when they discover their clone plants are sick and in no shape to move onto their next stage of growth. With only 1-2 weeks to fix the issue and nurse the plants back to health, Jim has no choice but to stay back on the farm and send Larry to Mississippi in his place. A decision Chris adamantly disagrees with. Larry has finally started to find his footing in Oregon. But will he buckle under the pressure of walking a mile in Jim's shoes?

The prime minister of Albania presents Jim Belushi with the opportunity of a lifetime, but Chris isn't high on the idea.